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Light Shed on Link Between Depression, Dementia

By Dennis Thompson

HealthDay Reporter

WEDNESDAY, July 30, 2014 (HealthDay News) — More seasoned individuals with misery are more likely to create dementia, but researchers have been incapable to clarify the exact nature of the relationship between the two.

Particularly, they haven’t been able to figure out the heading in which the relationship works — does depression help bring on dementia, or does dementia cause individuals to gotten to be depressed?

A modern ponder published online July 30 in the diary Neurology sheds more light on the secret.

Discouragement may be a chance figure for dementia, analysts report, and individuals with more side effects of misery tend to suffer a more fast decline in thinking and memory skills. While the study found an association between the two, it did not demonstrate a cause-and-effect relationship.

Misery accounted for approximately 4.4 percent of the contrast in mental decrease that may not be credited to dementia-related damage found in the brain, the analysts said.

“Typically a hazard factor we ought to take genuinely,” said lead author Robert Wilson, senior neuropsychologist at the Surge Alzheimer’s Disease Center at Surge College. “Treating misery can reduce the hazard of dementia in more seasoned individuals.”

The consider included over 1,700 people, with an average age of 77, who had no thinking or memory problems at the start of the study.

Members were screened every year for side effects of misery, such as forlornness and need of craving, and took tests on their thinking and memory aptitudes for an average of eight a long time.

Amid the study, about half of the participants created gentle problems with memory and considering capacities that regularly appear as a forerunner to Alzheimer’s disease. A add up to of 315 people, or 18 percent, created dementia.

A total of 680 individuals died amid the consider, and post-mortem examinations were performed on 582 of them to search for the plaques and tangles within the brain that are the signs of dementia and other signs of damage within the brain.

The investigators found that high levels of discouragement earlier to a conclusion of dementia are linked to a more drastic diminish in thinking and memory skills later on.

On the other hand, onset of dementia did not appear to be associated with an increment in discouragement. In reality, the inverse appeared to be true.

“We found that people who are developing dementia did not ended up more depressed as they developed dementia, they really became less discouraged,” Wilson said.

“As individuals lose their considering and memory skills, it becomes harder to become discouraged and stay depressed,” he continued. “Discouragement depends on a certain continuity of experience that gets to be disrupted as you develop dementia. It’s left to the rest of us to feel depressed as we observe our loved ones slip into dementia.”

However, the analysts found no relationship between discouragement and dementia-related harm within the brain.

That could mean that treating depression will only fight off a parcel of the thinking and memory decrease that happens with age, said Dr. Alan Manevitz, a clinical therapist at Lenox Hill Clinic in Unused York City.

“Clearly, going to to depression amid one’s life, rather like work out or eating right, will lead to at least conceding a few of the mental decay that comes with maturing,” Manevitz said. “Also, if you treat depressive indications, you may be able to turn around some part of the decline that’s related to the depression.”

Future inquire about now ought to pivot to deciding precisely how sadness impacts the chance of dementia, Wilson said.

“We must try to recognize structures and capacities within the brain that are connected to sadness in ancient age and may offer assistance explain depression’s interface to dementia,” he said. “That gives us a much better chance of knowing how we should best treat misery in a way that will move the bar and diminish risk of dementia.”

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