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Antidepressants Don’t Help Bipolar

Walk 28, 2007 — Including antidepressants to mood-stabilizing drugs may not help — or hurt — the treatment of bipolar depression, the depressive phase of bipolar clutter.

Researchers report that news online within the Unused Britain Journal of Medicine. They included Gary Sachs, MD, of Massachusetts General Clinic and Harvard Restorative School.

The study’s results “indicate that careful management of mood-stabilizer drugs is a sensible alternative to including antidepressant medicine for treating bipolar misery,” Sachs says in a news discharge from the National Established of Mental Health.

Bipolar Sadness Study

The think about included 366 bipolar misery patients at 22 centers over the U.S.

To begin with, the researchers made beyond any doubt all of the patients were taking appropriate doses of mood-stabilizing drugs such as lithium. Another, they part the patients into two bunches.

One group received an dormant sugar pill (placebo) in expansion to their mood-stabilizing drugs.

Patients within the other bunch gotten one of two antidepressants — paroxetine or bupropion — together with the mood-stabilizing drugs.

Paroxetine is sold generically and under the brand name Paxil. Bupropion is sold generically and beneath the brand title Wellbutrin XL. The study doesn’t indicate whether the non specific or brand-name adaptations were utilized.

Paroxetine and bupropion are commonly used with temperament stabilizers to treat bipolar discouragement, but the FDA hasn’t approved any antidepressant to treat the disorder, note Sachs and colleagues.

Both persistent groups took their assigned drugs for up to 26 weeks.

During that time, the analysts checked how numerous in each bunch had eight sequential weeks without major disposition swings.

No Advantage Seen With Antidepressants

Adding antidepressants to the mood-stabilizing drugs didn’t appear to influence the comes about.

Approximately 23% of the antidepressant gather met the study’s benchmark (eight successive weeks without major disposition swings), compared with 27% of the placebo group.

The difference was so small that it was not critical, the analysts note. They found no advantage for either antidepressant over a placebo.

Be that as it may, the upper group too had no more side effects or hyper scenes than the gather taking a fake treatment, the study appears.

‘Surprising’ Comes about

The discoveries “come as a astonish,” since European studies have upheld antidepressants’ viability in treating bipolar discouragement, says a web publication in the Modern England Diary of Pharmaceutical written by R.H. Belmaker, MD. Belmaker works at Ben Gurion University and Beersheva Mental Wellbeing Center in Beersheva, Israel.

Advance ponders are needed to see in the event that a few antidepressants are more helpful than others in treating bipolar misery, Belmaker says.

Sachs and colleagues also call for more inquire about, particularly long-term studies since their think about was moderately brief.

The think about was financed by the National Institute of Mental Wellbeing. In the diary, Sachs and colleagues note money related ties to various medicate companies; Belmaker says he has no potential clashes of intrigued.

The study and publication appear in the journal’s “Online To begin with” version and will be distributed in its print version on April 26.

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